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Meta-analyses of genome-wide association studies (GWAS) have identified a sizable quantity of loci linked with areal bone mineral density (aBMD) [1]. aBMD is often a complex trait, obtained from a 2-dimensional projectional scan with the given bone with dual x-ray absorptiometry (DXA). Skeletal sites that are measured in this way, including the lumbar spine and hip, comprise a mixture of cortical bone (compact bone comprising the outer shell), and trabecular bone (a network of thin interconnecting plates inside the marrow cavity of vertebrae and the finish of long bones). The lumbar spine features a comparatively high proportion of trabecular bone, whereas the hip has a larger proportion of cortical bone. DXAmeasured aBMD depends not only on bone cross-sectional size but also on apparent volumetric bone mineral density that is largely determined by trabecular microstructure and cortical thickness [7]. Although aBMD could be the gold typical for diagnosing osteoporosis, it fails to supply a detailed skeletal phenotype vital to discern traits such as trabecular volumetric BMD (vBMD), cortical vBMD and bone microstructural parameters. Prior research working with DXA have demonstrated that age is really a key predictor of fracture danger independent of aBMD. While this aBMD independent impact of age has been attributed to poor bone “quality”, the st.