Name: Human IDH1 Recombinant Protein (R132H, C-8His)
Synonyms: Isocitrate Dehydrogenase [NADP] Cytoplasmic;IDH;Cytosolic NADP-Isocitrate Dehydrogenase;IDP;NADP(+)-Specific ICDH;Oxalosuccinate Decarboxylase;IDH1;PICD
Expression host: E.coli
Sequence: Met1-Leu414(Arg132His)
Accesstion: O75874
Species: Human
Mol_Mass: 48.1 kDa
AP_Mol_Mass: 40-50 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 4% Sucrose, 50% glycerol, 0.02% Tween80, pH 8.0.
Reconstitution: Not Applicable
Background: Isocitrate Dehydrogenase [NADP] Cytoplasmic (IDH1) belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 exists as a homodimer; binding one magnesium or manganese ion per subunit. Mutations of IDH1 have been shown to cause metaphyseal chondromatosis with aciduria and are involved in the development of glioma. IDH plays a role in the regeneration of NADPH for intraperoxisomal reductions; such as the conversion of 2; 4-dienoyl-CoAs to 3-enoyl-CoAs; as well as in peroxisomal reactions that consume 2-oxoglutarate; namely the α-hydroxylation of phytanic acid.
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