Name: Human IDO2 Recombinant Protein (His Tag)

Synonyms: INDOL1

Expression host: E.coli

Sequence: Met14-Gly420

Accesstion: Q6ZQW0

Species: Human

Mol_Mass: 46.5 kDa

AP_Mol_Mass: 45 kDa

Tag: C-His

Purity: > 95 % as determined by reducing SDS-PAGE.


Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10% Glycerol, 1mM EDTA, 250mM NaCl, pH 8.0.

Reconstitution: Not Applicable

Background: Indoleamine 2,3-dioxygenase-like protein 1(IDO2) belongs to the indoleamine 2,3-dioxygenase family. IDO2 can be detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. It also expressed at low level in testis and thyroid but not expressed in the majority of human tumor samples. IDO2 catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. It involved in immune regulation. IDO1 and IDO2 are 2 distinct enzymes which catalyze the same reaction. IDO2 affinity for tryptophan is much lower than that of IDO1. 50 % of Caucasians harbor polymorphisms which abolish IDO2 enzymatic activity. IDO2 is expressed in human tumors in an inactive form: tryptophan degradation is entirely provided by IDO1 in these cells.IDO2 may play a role as a negative regulator of IDO1 by competing for heme-binding with IDO1. Lowefficiency IDO2 enzymes have been conserved throughout vertebrate evolution, whereas higher efficiencyIDO1 enzymes are dispensable in many lower vertebrate lineages. IDO1 may have arisen by geneduplication of a more ancient proto-IDO gene before the divergence of marsupial and eutherian(placental) mammals.

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites:
Popular product recommendations:
GMP Fibronectin Protein
uPAR Protein
Popular categories:
Ubiquitin-Specific Peptidase 29