Name: Human Hyaluronidase-1/HYAL1 Recombinant Protein (His Tag)
Synonyms: Hyaluronidase-1;Hyal-1;Hyaluronoglucosaminidase-1;Lung Carcinoma Protein 1;LuCa-1;HYAL1;LUCA1
Expression host: HEK293 Cells
Sequence: Phe22-Trp435
Accesstion: Q12794
Species: Human
Mol_Mass: 47.2 kDa
AP_Mol_Mass: 50-65 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.
Reconstitution: Not Applicable
Background: Hyaluronidase-1 (HYAL1) is a secreted lysosomal hyaluronidase that belongs to the glycosyl hydrolase 56 family. HYAL1 contains one EGF-like domain and is highly expressed in the liver, kidney, and heart, but it is weakly expressed in the lung, placenta, and skeletal muscle. HYAL1 is thought to be involved in cell proliferation, migration, and differentiation. It may play a role in promoting tumor progression and blocking the TGFB1-enhanced cell growth. Mutations in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.
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