Name: Human IA2/PTPRN Recombinant Protein (aa 607-Asn686 & aa 795-888, His Tag)

Synonyms: Receptor-type tyrosine-protein phosphatase-like N;R-PTP-N;Islet cell antigen 512;ICA 512;Islet cell autoantigen 3;PTP IA-2;PTPRN;ICA3;ICA512

Expression host: E.coli

Sequence: Gln607-Asn686&Trp795-Leu888

Accesstion: Q16849

Species: Human

Mol_Mass: 22.9 kDa

AP_Mol_Mass: 26-30 kDa

Tag: N-His

Purity: > 90 % as determined by reducing SDS-PAGE.


Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, 1mM EDTA, pH 8.0.

Reconstitution: Not Applicable

Background: Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain; is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules; such as their biogenesis; trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity; may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera; and thus may be a potential target of autoimmunity in diabetes mellitus.

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