Name: Human HMGB1 Recombinant Protein

Synonyms: High Mobility Group Protein B1;High Mobility Group Protein 1;HMG-1;HMGB1;HMG1

Expression host: E.coli

Sequence: Pro92-Val176

Accesstion: P09429

Species: Human

Mol_Mass: 10.0 kDa

AP_Mol_Mass: 13 kDa


Purity: > 95 % as determined by reducing SDS-PAGE.


Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Formulation: Lyophilized from a 0.2 μm filtered solution of 50mM HEPES-Na, 500mM NaCl, 0.6mM DTT, pH 7.9.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information i

Reconstitution: Please refer to the printed manual for detailed information.

Background: High mobility group protein B1 is a member of the HMGB family consisting of three members; HMGB1; HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein; HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile; it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte; T cell; dendritic cell activities in inflammatory responses.

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites:
Popular product recommendations:
HNF 4 alpha (HNF4A) Recombinant Protein
Nucleocapsid Protein NTD domain
Popular categories: