Name: Human HMBS Recombinant Protein (His Tag)
Synonyms: Porphobilinogen Deaminase;PBG-D;Hydroxymethylbilane Synthase;HMBS;Pre-Uroporphyrinogen Synthase;HMBS;PBGD;UPS
Expression host: HEK293 Cells
Sequence: Ser2-His361
Accesstion: P08397
Species: Human
Mol_Mass: 40.5 kDa
AP_Mol_Mass: 47 kDa
Tag: C-His
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, 5% mannitol, 50% Glycerol, 0.1% Tween80, pH7.4.
Reconstitution: Not Applicable
Background: Porphobilinogen Deaminase (HMBS) is a member of the HMBS family. PBGD is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. HMBS is involved in the production of heme, which is important for all of the body’s organs, although it is most abundant in the blood, bone marrow, and liver. In addition, Heme is an essential component of iron-containing proteins called hemoproteins, including hemoglobin. Defects in PBGD are the cause of acute intermittent porphyria.
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