Name: Human GCDH Recombinant Protein (His Tag)
Synonyms: Glutaryl-CoA Dehydrogenase Mitochondrial;GCD;GCDH
Expression host: E.coli
Sequence: Arg45-Lys438
Accesstion: Q92947
Species: Human
Mol_Mass: 45.0 kDa
AP_Mol_Mass: 41 kDa
Tag: N-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.4.
Reconstitution: Not Applicable
Background: Glutaryl-CoA Dehydrogenase Mitochondrial (GCDH) is an enzyme that acts upon glutaryl-coenzyme A, creating crotonyl-coenzyme A. It plays a role in the metabolism of lysine, hydroxylysine and tryptophan. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive Glutaryl-CoA and electron-transfer flavoprotein to (E)-but-2-enoyl-CoA, CO2 and reduced electron-transfer flavoprotein. A defect in this enzyme is associated with neurological condition glutaric acidemia type 1 and cause a progressive form of early-onset generalized dystonia.
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