Name: Human GAS6 (C-6His)
Synonyms: AXLLG;AXLLGAXL stimulatory factor;AXSFAXL receptor tyrosine kinase ligand;Gas6;GAS-6;growth arrest-specific 6;growth arrest-specific protein 6
Expression host: HEK293 Cells
Sequence: Ala31-Ala678
Accesstion: Q14393-2
Species: Human
Mol_Mass: 72.7 kDa
AP_Mol_Mass: 80-90 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Reconstitution: Not Applicable
Background: GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
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