Name: Human PPP1R1A Recombinant Protein (His Tag)

Synonyms: Protein Phosphatase 1 Regulatory Subunit 1A;Protein Phosphatase Inhibitor 1;I-1;IPP-1;PPP1R1A;IPP1

Expression host: E.coli

Sequence: Met 1-Val171

Accesstion: AAH22470.1

Species: Human

Mol_Mass: 20.0 kDa

AP_Mol_Mass: 18 kDa

Tag: C-His

Purity: > 90 % as determined by reducing SDS-PAGE.


Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, 50% Glycerol, pH 8.5.

Reconstitution: Not Applicable

Background: Protein Phosphatase 1 Regulatory Subunit 1A (PPP1R1A) is an inhibitor of protein-Phosphatase 1. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation. In hormonal control of glycogen metabolism, IPP-1 protein plays important function. Hormones can elevate intracellular cAMP level and elevate IPP-1 activity. PPP1R1A activation caused cAMP increase , cAMP control over proteins that are not directly phosphorylated by PKA following a rise in intracellular calcium. IPP-1 is inactivated by calcineurin (PP2B). Multiple domains in IPP-1 target cellular PP1 complexes.

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