Name: Human POMGNT1 Recombinant Protein (His Tag)

Synonyms: Protein O-Linked-Mannose Beta-1;2-N-Acetylglucosaminyltransferase 1;POMGnT1;UDP-GlcNAc:Alpha-D-Mannoside Beta-1;2-N-Acetylglucosaminyltransferase I.2;POMGNT1;MGAT1.2

Expression host: HEK293 Cells

Sequence: Leu59-Thr660

Accesstion: Q8WZA1

Species: Human

Mol_Mass: 69.3 kDa

AP_Mol_Mass: 74 kDa

Tag: C-His

Purity: > 90 % as determined by reducing SDS-PAGE.


Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.5.

Reconstitution: Not Applicable

Background: Protein O-Linked-Mannose β-1 2-N-Acetylglucosaminyltransferase 1 (POMGNT1) belongs to the Glycosyltransferase 13 family. Amino acid residues between 299-311 are important for both protein expression and enzymatic activity. The minimal catalytic domain is located between positions 299-651. It is suggested that the stem domain of the soluble form is unnecessary for activity, but that some amino acids play a crucial role in the membrane-bound form. Defects in POMGNT1 are the cause of muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies type A3 (MDDGA3).

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