Name: Human Podoplanin/PDPN Recombinant Protein (His Tag)

Synonyms: Podoplanin;Aggrus;Glycoprotein 36;Gp36;PA2.26 Antigen;T1-Alpha;T1A;PDPN;GP36

Expression host: HEK293 Cells

Sequence: Ala23-Leu131

Accesstion: Q86YL7

Species: Human

Mol_Mass: 12.2 kDa

AP_Mol_Mass: 20-30 kDa

Tag: C-His

Purity: > 95 % as determined by reducing SDS-PAGE.


Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed man

Reconstitution: Please refer to the printed manual for detailed information.

Background: Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta; lung; skeletal muscle and brain; weakly expressed in brain; kidney and liver. In placenta; PDPN expressed on the apical plasma membrane of endothelium; in lung; expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes; induces changes in cell morphology with transfected cells showing an elongated shape; numerous membrane protrusions; and major reorganization of the actin cytoskeleton; increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless; it doesn’t have any effect on amino acid transport and the aquaporin-type water channels.

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