Name: Human Alpha-Galactosidase A/GLA Recombinant Protein (His Tag)

Synonyms: Alpha-Galactosidase A;Alpha-D-Galactosidase A;Alpha-D-Galactoside Galactohydrolase;Melibiase;Agalsidase;GLA;GLAL

Expression host: HEK293 Cells

Sequence: Leu32-Leu429

Accesstion: P06280

Species: Human

Mol_Mass: 46.4 kDa

AP_Mol_Mass: 50-60 kDa

Tag: C-His

Purity: > 95 % as determined by reducing SDS-PAGE.


Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.

Reconstitution: Not Applicable

Background: α-Galactosidase A is a homodimeric glycoprotein that belongs to the glycosyl hydrolase 27 family. It is a lysosomal enzyme and used as a long-term enzyme replacement therapy in patients with a confirmed diagnosis of Fabry disease. α-Galactosidase A can hydrolyze terminal α-galactosyl moieties from glycolipids and glycoproteins and catalyze the hydrolysis of melibiose into galactose and glucose. Defects α-Galactosidase A are the cause of Fabry disease (FD) which is a rare X-linked sphingolipidosis disease with glycolipid accumulates in many tissues. The disease consists of an inborn error of glycosphingolipid catabolism. FD patients show systemic accumulation of globotriaoslyceramide (Gb3) and related glycosphingolipids in the plasma and cellular lysosomes throughout the body. Patients may show ocular deposits, febrile episodes, and burning pain in the extremities. Death results from renal failure, cardiac or cerebral complications of hypertension or other vascular disease.

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites:
Popular product recommendations:
CCN2/CTGF Protein
Coagulation Factor VII/F7 Protein
Popular categories:
Dual Specificity Protein Phosphatase 14 (DUSP14)
Constitutive Androstane Receptor