Name: Human Legumain/LGMN Recombinant Protein (His Tag)
Synonyms: Legumain;Asparaginyl Endopeptidase;Protease Cysteine 1;LGMN;PRSC1
Expression host: HEK293 Cells
Sequence: Ile18-Tyr433
Accesstion: AAH03061.1
Species: Human
Mol_Mass: 48.7 kDa
AP_Mol_Mass: 56 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: Legumain is a lysosomal cysteine protease which is a member of the peptidase C13 family. Though it is found in many tissues, it is highly expressed in the kidney, heart, and placenta. Legumain has a strict specificity for hydrolysis of asparaginyl bonds and can also cleave aspartyl bonds slowly, especially under acidic conditions. Over-expression Legumain in tumors is significant for invasion and metastasis. In addition, Legumain may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system and negative regulation of neuron apoptosis.
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