Hermanides J, Bosman RJ, Vriesendorp TM, Dotsch R, Rosendaal FR, Zandstra DF, Hoekstra JB, DeVries JH: Hypoglycemia is related with intensive care unit mortality. Crit Care Med 2010, 38(six):1430-1434. eight. Egi M, Bellomo R, Stachowski E, French CJ, Hart G: Variability of blood glucose concentration and short-term mortality in critically ill sufferers. Anesthesiology 2006, 105(two):244-252. 9. Krinsley JS: Glycemic variability: a strong independent predictor of mortality in critically ill individuals. Crit Care Med 2008, 36(11):3008-3013. ten. Badawi O, Waite MD, Fuhrman SA, Zuckerman IH: Association in between intensive care unit-acquired dysglycemia and in-hospital mortality. Crit Care Med 2012, 40(12):3180-3188. 11. Dungan KM, Braithwaite SS, Preiser JC: Stress hyperglycaemia. Lancet 2009, 373(9677):1798-1807.Crucial messages Totally automated closed-loop glucose handle according to subcutaneous sensor glucose is feasible. Closed-loop therapy offered protected, efficient, and constant glucose handle with out increasing the threat of hypoglycemia inside a compact group of patients more than a 48-hour period. Closed-loop therapy was superior to a regional sliding-scale therapy protocol. Nurse intervention will not be necessary in the course of closed-loop therapy, apart from calibrating a subcutaneous glucose monitor. Automated administration of dextrose augmented the potential of closed-loop therapy to prevent low glucose levels.Abbreviations CGM: Continuous glucose monitoring; CL: closed-loop; NCCU: Neurosciences Vital Care Unit at Addenbrooke’s Hospital: Cambridge: UK.Leelarathna et al. Crucial Care 2013, 17:R159 http://ccforum/content/17/4/RPage 11 of12. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in critically ill individuals.Cyclic AMP web N Engl J Med 2001, 345(19):1359-1367.Guanine Purity & Documentation 13.PMID:24605203 Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R: Intensive insulin therapy within the health-related ICU. N Engl J Med 2006, 354(5):449-461. 14. NICE-SUGAR Study Investigators, Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, Hebert Computer, Heritier S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh JA, Norton R, Potter J, Robinson BG, Ronco JJ: Intensive versus traditional glucose manage in critically ill sufferers. N Engl J Med 2009, 360(13):1283-1297. 15. Preiser JC, Devos P, Ruiz-Santana S, Melot C, Annane D, Groeneveld J, Iapichino G, Leverve X, Nitenberg G, Singer P, Wernerman J, Joannidis M, Stecher A, Chiolero R: A potential randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: The Glucontrol Study. Intensive Care Med 2009, 35(10):1738-1748. 16. Griesdale DE, de Souza RJ, van Dam RM, Heyland DK, Cook DJ, Malhotra A, Dhaliwal R, Henderson WR, Chittock DR, Finfer S, Talmor D: Intensive insulin therapy and mortality among critically ill patients: a metaanalysis including NICE-SUGAR study data. CMAJ 2009, 180(eight):821-827. 17. Van den Berghe G: Intensive insulin therapy in the ICU: reconciling the evidence. Nature Rev Endocrinol 2012, 8(6):374-378. 18. Van den Berghe G, Schetz M, Vlasselaers D, Hermans G, Wilmer A, Bouillon R, Mesotten D: Clinical critique: intensive insulin therapy in critically ill sufferers: NICE-SUGAR or Leuven blood glucose target J Clin Endocrinol Metab 2009, 94(9):3163-3170. 19. Van Herpe T, De.