D (Figure 1). Only retrospective verification of the specimen obtained for the duration of preoperative FNAB, revealed the presence of R-S cell (Figure 2). Consulting hematologist decided to postpone chemotherapy for the time after delivery. Within the 36th week of pregnancy, the symptoms of preterm labor occurred and the patient delivered a healthy boy by caesarean section. Three weeks later the patient was admitted towards the department of hematology, where thorough clinical evaluation, bone marrow biopsy and imaging research were performed to establish the advancement in the illness. The patient presented involvement of cervical and thoracic lymph nodes, splenomegaly and clinical symptoms (fever 38 and sweating), therefore IVB stage of HL in line with Ann Arbor classification was diagnosed.Anti-Mouse IFNAR1 Antibody Autophagy She received eight courses of ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine) chemotherapy and reached remission. During 10-year follow-up period, no relapse of lymphoma was detected. Four years following the therapy, the patient got pregnant and gave birth to healthier female twins. She continues to be followed up in an endocrine outpatient clinic and her hormonal balance is maintained with 100 g of L-thyroxin.Case reportPatientIn April 2002, 29-year-old pregnant lady was referred for ultrasound examination from the neck as a consequence of considerably enlarged cervical lymph nodes detected on palpation. On sonography the packages of lymph nodes with coinciding hypoechogenic ill-defined thyroid lesion were demonstrated, what raised suspicion of advanced thyroid cancer. Patient underwent fine-needle aspiration biopsy (FNAB) of both thyroid lesion and lymph nodes. The result of cytological examination was constant with suspicion of medullary thyroid cancer. At the time of diagnosis, the patient was 29 weeks pregnant with her initially child. As a consequence of suspicion of metastatic medullary thyroid carcinoma, decision on surgical remedy wasFigure 1 Histopathological examination of your material obtained during thyroidectomy – Hodgkin lymphoma – mixed cellularity (MC) kind in Patient 1 (H E, magnification ten).Lamivudine manufacturer Szczepanek-Parulska et al.PMID:23614016 Diagnostic Pathology 2013, eight:116 http://www.diagnosticpathology.org/content/8/1/Page three ofFigure 2 Retrospective verification of cytological specimen obtained preoperatively through fine-needle aspiration biopsy of the thyroid within the Patient 1. An arrow indicates Reed-Sternberg cell, presence of which could deliver preoperative diagnosis of Hodgkin lymphoma (H E, magnification 400).Patientmy. Immunohistochemical research have been performed and showed the tumor cells expressing CD30+, CD15+, Ki67+. Tumor cells had been negative for D3-, CD20-, CKAE1/3, EBV-LMP1. Therefore a final diagnosis of extra-lymphatic classical HL (nodular sclerosis subtype) with the thyroid was made (Figures 3 and 4). The patient was subsequently referred for the department of hematology. Around the base of clinical image, imaging examinations and bone marrow assessment, she was classified for stage IIE of disease in Ann Arbor classification. The patient was subjected to combined chemotherapy (12 cycles of ABVD) and radiotherapy, starting from December 2008. The following imaging research, which includes chest X-ray and positron emission tomography had been performed to confirm remission status and did not reveal any pathological adjustments. The individuals observation period has now reached 4 years and is uneventful. She continues to be followed-up in an endocrinology outpatient clinic and remains both clinically and biochemicall.