Name: Human IL-36 Receptor Antagonist Recombinant Protein/IL-36RN/IL-1F5
Synonyms: Interleukin-36 Receptor Antagonist Protein;FIL1 Delta;IL-1-Related Protein 3;IL-1RP3;Interleukin-1 HY1;IL-1HY1;Interleukin-1 Delta;IL-1 Delta;Interleukin-1 Family Member 5;IL-1F5;Interleukin-1 Receptor Antagonist Homolog 1;IL-1ra Homolog 1;Interleukin-1-Like Protein 1;IL-1L1;IL36RN;FIL1D;IL1F5;IL1HY1;IL1L1;IL1RP3
Expression host: E.coli
Sequence: Val2-Asp155
Accesstion: Q9UBH0
Species: Human
Mol_Mass: 16.8 kDa
AP_Mol_Mass: 17 kDa
Tag: None
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family). IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9). Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity.
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