Name: Human IL-10/Interleukin-10 Recombinant Protein
Synonyms: Interleukin-10;IL-10;Cytokine synthesis inhibitory factor;CSIF;IL10;RP11-262N9.1;IL10A;MGC126450;MGC126451;TGIF
Expression host: HEK293 Cells
Sequence: Ser19-Asn178
Accesstion: P22301
Species: Human
Mol_Mass: 18.6 kDa
AP_Mol_Mass: 16 kDa
Tag: None
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Interleukin 10(IL10), also known as cytokine synthesis inhibitory factor (CSIF),is a secreted protein andbelongs to the IL-10 family. IL-10 is secreted by many activated hematopoietic cell types as well as hepaticstellate cells, keratinocytes, and placental cytotrophoblasts . IL-10 is an anti-inflammatory TH2 cytokinethat has a critical role in limiting the immune response to pathogens to prevent host damage. As IL-10 inproduced in several T helper populations, it is proposed that it provides a feedback loop to limit theeffector functions of macrophages and DCs on T cells. Once expressed, IL-10 signals through the IL-10receptor (IL-10R) to activate STAT3. As IL-10 is a strong inhibitor of inflammation, it has become a viablebiomarker for various diseases and conditions as well as a therapeutic molecule for certain conditions. Inaddition to elevated levels in parasitic infection, high expression levels of IL-10 are also found in retroviralinfections inducing immunodeficiency. The immunosuppressive properties of IL-10 suggest a possibleclinical use of IL-10 in suppressing rejections of grafts after organ transplantations.
MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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