Name: Human HVEM/TNFRSF14 Recombinant Protein (Fc Tag)
Synonyms: Tumor Necrosis Factor Receptor Superfamily Member 14;Herpes Virus Entry Mediator A;Herpesvirus Entry Mediator A;HveA;Tumor Necrosis Factor Receptor-Like 2;TR2;CD270
Expression host: HEK293 Cells
Sequence: Leu39-Val202
Accesstion: Q92956
Species: Human
Mol_Mass: 44.5 kDa
AP_Mol_Mass: 50-60 kDa
Tag: C-Fc
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily; and it can both promote and inhibit T cell activity. HVEM is highly expressed on na?ve CD4+ T cells; CD8+ T memory cells; regulatory T cells; dendritic cells; monocytes; and neutrophils. It functions as a receptor for BTLA; CD160; LIGHT/TNFSF14; and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell; monocyte; and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast; HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells; where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD; which binds HVEM to initiate membrane fusion; can antagonize both BTLA and LIGHT binding.
MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
PDGF-AA Protein
IGFBP-5 Protein
Popular categories:
Ubiquitin-Specific Peptidase 34
Siglec-5/CD170