Name: Human HPD/4HPPD Recombinant Protein (His Tag)

Synonyms: 4-Hydroxyphenylpyruvate Dioxygenase;4-Hydroxyphenylpyruvic Acid Oxidase;4HPPD;HPD;HPPDase;HPD;PPD

Expression host: E.coli

Sequence: Met 1-Met393

Accesstion: P32754

Species: Human

Mol_Mass: 47.1 kDa

AP_Mol_Mass: 40-50 kDa

Tag: N-His

Purity: > 95 % as determined by reducing SDS-PAGE.


Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 50mM NaCl, 1mM DTT, 20% Glycerol, pH 8.0.

Reconstitution: Not Applicable

Background: 4-Hydroxyphenylpyruvate Dioxygenase (4HPPD) belongs to the 4HPPD family. 4HPPD is a key enzyme in the degradation of tyrosine, which catalyzes the second reaction in the catabolism of tyrosine the conversation of 4-hydroxyphenylpyruvate to homogentisate. 4HPPD exists in homodimer forms, which uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. When the active 4HPPD enzyme concentration is low in the human body, it results in high levels of tyrosine concentration in the blood, which can cause mild mental retardation at birth, and degradation in vision as a patient grows older.

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