Name: Human HIP2/UBE2K Recombinant Protein (His Tag, SUMO Tag)
Synonyms: Ubiquitin-Conjugating Enzyme E2 K;Huntingtin-Interacting Protein 2;HIP-2;Ubiquitin Carrier Protein;Ubiquitin-Conjugating Enzyme E2-25 kDa;Ubiquitin-Conjugating Enzyme E2(25K);Ubiquitin-Conjugating Enzyme E2-25K;Ubiquitin-Protein Ligase;UBE2K;HIP2;LIG
Expression host: E.coli
Sequence: Met 1-Asn200
Accesstion: P61086
Species: Human
Mol_Mass: 34.5 kDa
AP_Mol_Mass: 38 kDa
Tag: N-His-SUMO
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 8% Sucrose, 100mM NaCl, 0.05% Tween 80, pH 7.5.
Reconstitution: Not Applicable
Background: Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain; with highest levels found in cortex and striatum; and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins; such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition; UBE2K is involved in Alzheimer’s disease; Huntington’s disease and antigen processing through its interaction with huntingtin; and MHC-heavy chain proteins.
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