Name: Human GFRRA2 Recombinant Protein ((Fc & His Tag)

Synonyms: GDNF family Receptor Alpha-2;GDNF Receptor Alpha-2;GDNFR-Alpha-2;GFR-Alpha-2;GDNF Receptor Beta;GDNFR-Beta;Neurturin Receptor Alpha;NRTNR-Alpha;NTNR-Alpha;RET Ligand 2;TGF-Beta-Related Neurotrophic Factor Receptor 2;GFRA2;GDNFRB;RETL2;TRNR2

Expression host: HEK293 Cells

Sequence: Ser22-Ser441

Accesstion: O00451

Species: Human

Mol_Mass: 74.7 kDa

AP_Mol_Mass: 120 kDa

Tag: C-Fc-His

Purity: > 95 % as determined by reducing SDS-PAGE.


Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the print

Reconstitution: Please refer to the printed manual for detailed information.

Background: GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.

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