Name: Human ABCG2 Recombinant Protein (His tag)
Synonyms: Broad substrate specificity ATP-binding cassette transporter ABCG2;ABCG2;ATP-binding cassette sub-family G member 2;Breast cancer resistance protein;CDw338
Expression host: E.coli
Sequence: Met 1-Gly 300
Accesstion: Q9UNQ0
Species: Human
Mol_Mass: 32.9 kDa
AP_Mol_Mass: 32 kDa
Tag: N-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from sterile PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Hematopoietic stem cells are known to express a membrane transporter molecule, known as P-glycoprotein (Pgp), that is encoded by the multidrug resistance gene 1 (MDR1) . Expression of Pgp appears to confer a proliferative advantage to stem cells through its anti-apoptotic effects . An additional transporter molecule known as ABCG2 (ATP-binding cassette gene 2) or Bcrp1 (Breast cancer resistance protein 1), first identified in a breast cancer cell line , is expressed on stem cells . ABCG2 belongs to a family of molecules that span the cell membrane six times and can exist as either homo or hetero dimers linked by a short intracellular flexible linker region that plays an important role in the efflux of a wide range of substrates
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