Name: Human Gankyrin/PSDM10 Recombinant Protein
Synonyms: 26S Proteasome Non-ATPase Regulatory Subunit 10;26S Proteasome Regulatory Subunit p28;Gankyrin;p28(GANK);PSMD10
Expression host: E.coli
Sequence: Met 1-Gly226
Accesstion: O75832
Species: Human
Mol_Mass: 24.4 kDa
AP_Mol_Mass: 26 kDa
Tag: None
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Reconstitution: Not Applicable
Background: Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
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