Name: Human Galectin-9/LGALS9 (N-GST)
Synonyms: Galectin-9;Gal-9;Ecalectin;Tumor antigen HOM-HD-21;LGALS9;Gal-9delta5
Expression host: E.coli
Sequence: Met1-Thr322
Accesstion: O00182-2
Species: Human
Mol_Mass: 62.2 kDa
AP_Mol_Mass: 60 kDa
Tag: N-GST
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 1M PBS, 100 mM GSH, 15% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin’s disease tissue. Galectin-9 binds galactosides and has high affinity for the Forssman pentasaccharide. Galectin-9 plays a role in thymocyte-epithelial interactions relevant to the biology of the thymus and Inhibits cell proliferation. Galectin-9 is a ligand for HAVCR2/TIM3 and induces T-helper type 1 lymphocyte (Th1) death. In addition, Galectin-9 suppresses tumor cell metastasis by interfering with the associations CD44, VCAM-1, Integrin α4β1
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