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He et al. Trials (2022) 23:317 PROTOCOLOpen AccessEffect of Baihu and Guizhi decoction in acute gouty arthritis: study protocol for any randomized controlled trialYikun He1, Chaoran Dai2, Jiaying Shen1, Qianwen Chen2, Jiandong Gao1,3,4, Xin Pan1 and Jing GanAbstractBackground: The prevalence rates of gout worldwide have enhanced annually. Acute gouty arthritis (AGA) accounts for any significant proportion of gout sufferers and causes serious physical and mental discomfort in sufferers. Controlling the occurrence and development of gout inflammation is the first step in the therapy of gout. The principle remedy drugs in gout are non-steroid anti-inflammatory drugs (NSAIDs), colchicine, and glucocorticoids, but these treatment options have lots of adverse reactions which limit their clinical application. Baihu and Guizhi decoction (BHGZ) is one of the classic prescriptions in the Synopsis in the Golden Chamber and is a fantastic prescription for AGA. Preceding clinical research have shown that BHGZ confers a robust advantage for treating AGA. Nevertheless, the literature shows a lack of high-quality RCT study on BHGZ with respect to AGA. Consequently, within this study, we use a randomized, double-blind, controlled study using a placebo to evaluate the clinical efficacy and security of BHGZ on the AGA of moist heat arthralgia spasm syndrome. Solutions: This study is actually a randomized, double-blind, controlled clinical trial. A total of 102 adult participants with AGA of moist heat arthralgia spasm syndrome might be enrolled, with balanced remedy allocation (1:1). The experimental intervention is going to be BHGZ plus the low-dose colchicine, as well as the handle intervention is going to be placebo plus the low-dose colchicine for ten days. To study the clinical efficacy (such as VAS score; joint tenderness, joint swelling, joint movement disorder; TCM proof efficacy score) as well as the modifications of inflammatory indexes. At the same time, the improvement of joint inflammation in sufferers with AGA will be observed from musculoskeletal ultrasound imaging, as well as the security evaluation will likely be carried out. Discussion: This study is going to be the very first placebo-controlled RCT to assess no matter if BHGZ plus low-dose colchicine have helpful effects on changing lowering inflammation of joints for patients with AGA of moist heat arthralgia spasm syndrome.Orexin A Cancer The results of this trial will assistance to supply evidence-based suggestions for clinicians.Desmosterol Description Trial registration: Chinese Clinical Trials Register ChiCTR1900024974.PMID:23551549 Registered on five August 2019 Key phrases: Baihu and Guizhi decoction, Acute gouty arthritis, Randomized controlled trial Correspondence: gaojiandong@hotmail; panxin66@163 Yikun He and Chaoran Dai contribute equally to this perform and are the cofirst authors. three Division of Ultrasonography, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 1 Department of Rheumatism, Shuguang Hospital Affiliated to Shanghai University of Classic Chinese Medicine, Shanghai 201203, China Full list of author information and facts is offered at the finish with the articleThe Author(s). 2022 Open Access This article is licensed below a Creative Commons Attribution four.0 International License, which per.