Name: Human Fumarase/FH Recombinant Protein
Synonyms: Fumarate Hydratase Mitochondrial;Fumarase;FH;FMRD;HLRCC;LRCC;MCL;MCUL1
Expression host: E.coli
Sequence: Ala45-Lys510
Accesstion: P07954
Species: Human
Mol_Mass: 50.2 kDa
AP_Mol_Mass: 45 kDa
Tag: None
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, pH 8.0.
Reconstitution: Not Applicable
Background: Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy and development delay.
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