Er open new avenues to become explored in managing this refractory organism. A summary of critique of literature of all of the clinical studies and case reports or PI keratitis is listed in Table 2 [3, eight, 10, 12, 159, 229, 324, 38, 68, 755].ACKNOWLEDGEMENTSThe authors wish to thank Dr. Joseph Gubert for providing microbiological pictures for the post. In addition they want to thank Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Pondicherry, India; Sankara Nethralaya, Chennai; The Ottawa Hospital, University of Ottawa Eye Institute, Ontario, Canada; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Usa of America; Aravind Eye Hospital and Postgraduate Institute of Ophthalmology Tirunelveli, Tamil Nadu, India; and ASG Eye Hospital, BT Road, Kolkata, India. Funding. No funding or sponsorship was received for this short article. Authorship. All named authors meet the International Committee of Healthcare Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity from the perform as a whole, and have provided their approval for this version to be published. Author Contributions. Idea and design and style: BG, KK, SA; drafting manuscript: BG, KK, SA, NS, VL, AV, KT, GI, BS, JG; vital revision of manuscript: BG, KK, SA, NS, AV, VL, KT; supervision: BG, SA, VL, NS GI, BS. All authors study and authorized the final manuscript. Disclosures. Bharat Gurnani, Kirandeep Kaur, Shweta Agarwal, Vaitheeswaran G Lalgudi, Nakul S. Shekhawat, Anitha Venugopal,Ophthalmol Ther (2022) 11:1629Koushik Tripathy, Geetha Iyer and Joseph Gubert have nothing at all to disclose. Compliance with Ethics Suggestions. This overview short article is according to previously conducted research. The write-up does not include any studies with human participants or animals performed by any of your authors. Open Access. This short article is licensed beneath a Creative Commons Attribution-NonCommercial four.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give suitable credit to the original author(s) plus the supply, present a link to the Creative Commons licence, and indicate if alterations had been produced.GPVI Protein Purity & Documentation The images or other third party material within this report are integrated in the article’s Inventive Commons licence, unless indicated otherwise in a credit line for the material.CXCL16 Protein Species If material is not incorporated within the article’s Inventive Commons licence as well as your intended use isn’t permitted by statutory regulation or exceeds the permitted use, you can have to have to receive permission directly from the copyright holder.PMID:23789847 To view a copy of this licence, stop by http:// H, Krajaejun T. History and perspective of immunotherapy for pythiosis. Vaccines. 2021;9: 1080. Gurnani B, Kaur K, Venugopal A, et al. Pythium insidiosum keratitis–a critique. Indian J Ophthalmol. 2022;70(four):11070. Bagga B, Sharma S, Madhuri Guda SJ, et al. Leap forward in the therapy of Pythium insidiosum keratitis. Br J Ophthalmol. 2018;102(12):16293. Mittal R, Jena SK, Desai A, Agarwal S. Pythium insidiosum keratitis: histopathology and speedy novel diagnostic staining strategy. Cornea. 2017;36(9): 11242.7.8.9.ten. Gurnani B, Christy J, Narayana S, Rajkumar P, Kaur K, Gubert J. Retrospective multifactorial analysis of Pythium keratitis and critique of literature. Indian J Ophthalmol. 2021;69(5):109501. 11. Sharma S, Balne PK, Motukupally SR, et al. Pythium insidiosu.