Esides the keywords indicating the brain area of interest for the certain studies (central nervous program, hypothalamus, medial preoptic region, preoptic area and brain), the other indexing terms largely referred towards the methodology utilized to investigate the relationship in between the MPOA and parenting. As observed from the results, the vast majority of studies inside the field was carried out on rats making use of SIRT2 Gene ID approaches to analyze protein expression inside the brain. Moreover, as emerged in the discussion on clusters, most of the research focused on the time period around pregnancy (pre- and postpartum). Furthermore, although the majority in the studies exploring the part in the MPOA in parenting had been carried out on females, analysis interest has not too long ago involved males and paternal behavior as well. 6. Conclusions Within this paper, we applied a scientometric evaluation to identify investigation trends in previous publications investigating the association involving the MPOA and parental behaviour. We discovered 4 important clusters that characterised significant time periods within this dynamic region of study in order of chronology: “C-Fos Expression”, “Lactating Rat”, “Medial Preoptic Region Interaction” and “Parental Behavior”. Initial study interest focused on examining an established physiological response within the brain associated with the maternal response (initial cluster) then, mainly by the study of lactating rats (second cluster), new models to explain maternal behavior were conceptualised. Subsequently, equipped with insight gathered from these new models, researchers turned their focus towards investigating brain circuitry beyond just the MPOA in controlling parental behaviour (third cluster). Lastly, probably the most current predominance in study appears at disentangling the a lot of elements of parental behaviour, such as paternal behavior and infanticide (fourth cluster). The keyword evaluation also identified terms, specifically those connected with brain regions and methodology, that extend beyond the clusters, revealing doable foundations for subsequent study contributing to this line of function. This study has some limitations which we outline here. Firstly, The publication sampling process employed specifies a constraint of identified keywords and phrases to become present in the titles, which, although it has the obvious advantage of streamlining the selection procedure, excludes relevant publications which might not happen to be captured [252]. Consequently, underlying Akt1 Inhibitor Storage & Stability themes within the study not reflected inside the publication titles, abstract or search phrases may have been overlooked. Next, only a handful of keywords have been utilized to extract source articles from a single database, Scopus. Extensions of this perform may perhaps consider utilizing alternative key phrases and like other databases (e.g., Web of Science) to decide irrespective of whether the pattern of outcomes hold. This specific scientometric strategy may possibly also be unable to completely encapsulate the extent with the trends within this investigation, especially in view of unpublished functions [253].Brain Sci. 2021, 11,13 ofAnother limitation on the scientometric approach is that it strongly relies on citations among documents. This strategy offers insight in to the trends of analysis, but it doesn’t capture the particular nature of your relations amongst co-cited papers. Analysing citations amongst documents leads to a bias towards previous publications. The truth is, documents published previously tend to have greater variety of citations as in comparison with much more current ones. This difference in the variety of.