Name: Human FBPase 1/FBP1 Recombinant Protein (E. coli, His Tag)
Synonyms: Fructose-1;6-Bisphosphatase 1;FBPase 1;D-Fructose-1;6-Bisphosphate 1-Phosphohydrolase 1;FBP1;FBP
Expression host: E.coli
Sequence: Ala2-Gln338
Accesstion: P09467
Species: Human
Mol_Mass: 37.9 kDa
AP_Mol_Mass: 38 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 1mM EDTA, 20% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: Fructose-1;6-Bisphosphatase 1 (FBPase 1) is a member of the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory protein; which catalyzes the hydrolysis of fructose 1;6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBPase 1 can assume an active R-state; or an inactive T-state. FBPase 1 deficiency is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis in newborn infants or young children. FBPase 1 coupled with phosphofructokinase (PFK) is involved in the metabolism of pancreatic islet cells.
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