Name: Human Cornulin/CRNN Recombinant Protein (His Tag)
Synonyms: Cornulin;53 kDa Putative Calcium-Binding Protein;53 kDa Squamous Epithelial-Induced Stress Protein;58 kDa Heat Shock Protein;Squamous Epithelial Heat Shock Protein 53;Tumor-Related Protein;CRNN;C1orf10;DRC1;PDRC1;SEP53
Expression host: E.coli
Sequence: Met 1-Ser140
Accesstion: Q9UBG3
Species: Human
Mol_Mass: 17.5 kDa
AP_Mol_Mass: 17 kDa
Tag: N-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When Cornulin is overexpressed in oral squamous carcinoma cell lines, it regulates negatively cell proliferation by the induction of G1 arrest.
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