Name: Human BMPRIA/ALK-3 Recombinant Protein (Fc & His Tag)
Synonyms: Bone Morphogenetic Protein Receptor Type-1A;BMP Type-1A Receptor;BMPR-1A;Activin Receptor-Like Kinase 3;ALK-3;Serine/Threonine-Protein Kinase Receptor R5;SKR5;CD292;BMPR1A;ACVRLK3;ALK3;10q23del
Expression host: HEK293 Cells
Sequence: Gln24-Arg152
Accesstion: P36894
Species: Human
Mol_Mass: 42.1 kDa
AP_Mol_Mass: 60 kDa
Tag: C-Fc-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A is a single-pass type I membrane protein and highly expressed in skeletal muscle. BMPR1A contains one GS domain and one protein protein kinase domain. BMPR1A is necessary for the extracellular matrix depostition by osteoblasts. BMPR1A can activate SMAD transcriptional regulators, binding with ligands. Defects in BMPR1A are a cause of juvenile polyposis syndrome, Cowden disease and hereditary mixed polyposis syndrome 2 (HMPS2).
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