Name: Human Dectin-1/CLEC7A Recombinant Protein (Fc Tag)
Synonyms: Beta-glucan receptor;BGR;CD369;CLEC7A;CLECSF12;CLECSF12DC-associated C-type lectin 1;Dectin1;Dectin-1;DECTIN1CANDF4;CANDF4;DECTIN1
Expression host: HEK293 Cells
Sequence: Thr66-Met247
Accesstion: Q9BXN2
Species: Human
Mol_Mass: 46.9 kDa
AP_Mol_Mass: 50-65 kDa
Tag: N-Fc
Purity: > 85 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by Dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection.
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