Name: Human Cystathionine γ-Lyase/CTH Recombinant Protein

Synonyms: Cystathionine Gamma-Lyase;Cysteine-Protein Sulfhydrase;Gamma-Cystathionase;CTH

Expression host: E.coli

Sequence: Met 1-Ser405

Accesstion: P32929

Species: Human

Mol_Mass: 44.7 kDa

AP_Mol_Mass: 38-50 kDa

Tag: None

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin:

Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 8% Sucrose, 0.05% Tween 80, pH8.0.

Reconstitution: Not Applicable

Background: Cystathionine Gamma-Lyase (CTH) belongs to the trans-sulfuration enzymes family. CTH exists as a homotetramer and interacts with CALM in a calcium-dependent manner. CTH breaks down cystathionine into cysteine, ammonia and 2-oxobutanoate. CTH catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine and has broad substrate specificity. Defects in CTH will lead to cystathioninuria, which is an autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine.

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