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TNF-α Recombinant monoclonal antibody (RMTNFA-1)
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Tumor necrosis factor α is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction.437982-89-3 Technical Information It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. The primary role of TNF is in the regulation of immune cells. TNF-α, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL-1 & IL-6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer’s disease, cancer, major depression, Psoriasis and inflammatory bowel disease (IBD).700874-72-2 MedChemExpress
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| Application IF, IHC (PS) | Clone RMTNFA-1 | Formulation Liquid.PMID:25905300 In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. | Host Rabbit | Immunogen Recombinant human TNF-α. | Isotype IgGκ | Recommendation Dilutions/Conditions Immunofluorescence (5-10 µg/mL)Immunohistochemistry (formalin-fixed paraffin sections) (5-10 µg/mL for 30 min at RT)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Species Reactivity Human | UniProt ID P01375 | Unit of Measure (UM) µg