Name: Human Complement Factor B/CFB Recombinant Protein (His Tag)
Synonyms: Complement Factor B;C3/C5 Convertase;Glycine-Rich Beta Glycoprotein;GBG;PBF2;Properdin Factor B;CFB;BF;BFD
Expression host: HEK293 Cells
Sequence: Thr 26-Leu764
Accesstion: AAH04143.1
Species: Human
Mol_Mass: 84.1 kDa
AP_Mol_Mass: 90-120 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Reconstitution: Not Applicable
Background: Complement Factor B (CFB) belongs to the peptidase S1 family of enzymes. It is expressed by hepatocytes and macrophages and localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. CFB which is a component of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.
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