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Smac/DIABLO monoclonal antibody (79-1-83)
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Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate.910463-68-2 medchemexpress Western blot analysis of Smac/Diablo.1195765-45-7 MedChemExpress Lane 1: MW marker, Lane 2: 293, Lane 3: HeLa, Lane 4: Jurkat, Lane 5: Vero. IHC Analysis: Human adrenal tissue stained with Smac/DIABLO, mAb (79-1-83) at 10µg/ml. IHC Analysis: Human tonsil tissue stained with Smac/DIABLO, mAb (79-1-83) at 10µg/ml. IHC Analysis: Human testis tissue stained with Smac/DIABLO, mAb (79-1-83) at 10µg/ml. Western blot analysis of Smac/Diablo. Lane 1: MW marker, Lane 2: 293, Lane 3: HeLa, Lane 4: Jurkat, Lane 5: Vero. IHC Analysis: Human adrenal tissue stained with Smac/DIABLO, mAb (79-1-83) at 10µg/ml. IHC Analysis: Human tonsil tissue stained with Smac/DIABLO, mAb (79-1-83) at 10µg/ml. IHC Analysis: Human testis tissue stained with Smac/DIABLO, mAb (79-1-83) at 10µg/ml.
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| Alternative Name Second mitochondria-derived activator of caspase | Application IHC (PS), WB | Clone 79-1-83 | Formulation Liquid.PMID:30725978 In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol. | Host Mouse | Immunogen Recombinant full length human Smac/DIABLO. | Isotype IgG2b | Recommendation Dilutions/Conditions Western Blot (1µg/ml, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from mouse ascites. | Species Reactivity Human, Monkey | UniProt ID Q9NR28 | Unit of Measure (UM) µg