The restoration of p53 tumor suppressor function through inhibition of its interaction with the E3 ubiquitin ligase MDM2 represents a promising therapeutic strategy in cancer treatment. However, this approach may…
**Background** The Wnt signaling pathway plays a critical role in regulating cell proliferation, differentiation, and epithelial homeostasis. Dysregulation of this pathway is frequently observed in various malignancies, where overactivation of…
HLA-DO is a nonclassical MHC class II molecule that negatively regulates the function of HLA-DM in catalyzing the removal of CLIP peptides from classical MHC class II molecules. This study…
**Background** Synthetic food colorants are widely used in the food industry to enhance the visual appeal of products. Among these, azo dyes are common due to their stability and vibrant…
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) has emerged as a pivotal marker in the field of stem cell biology, particularly within epithelial tissues such as the intestine, skin, mammary…