Name: Mouse CXCL2/MIP-2 Recombinant Protein
Synonyms: MIP-2;chemokine ligand 2;C-X-C motif chemokine 2;GRO beta;GRO2;GROB;Gro-beta;Growth-regulated protein beta;Macrophage Inflammatory Protein-2-alpha;melanoma growth stimulatory activity beta;cxcl2;MGSA-b;MGSA-beta;MIP2A;MIP2-alpha;SCYB2.
Expression host: E.coli
Sequence: Ala28-Asn100
Accesstion: P10889
Species: Mouse
Mol_Mass: 8.7 kDa
AP_Mol_Mass: 11 kDa
Tag: N-His
Purity: > 98 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from sterile PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs. Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.
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