Name: Mouse CD73/NT5E Recombinant Protein (His Tag)

Synonyms: 5′-nucleotidase;Ecto-5′-nucleotidase;CD73;5′-NT;AI447961;eNT;NT;Nt5 Protein

Expression host: HEK293 Cells

Sequence: Trp29-Phe550

Accesstion: Q61503

Species: Mouse

Mol_Mass: 58.8 kDa

AP_Mol_Mass: 60 kDa

Tag: C-His

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin:

Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 120mM NaCl, 4mM CaCl2, 20% Glycerol, pH 7.5.

Reconstitution: Not Applicable

Background: Mouse CD73 is a glycosyl phosphatidylinositol (GPI) anchored membrane protein that belongs to the 5′-nucleotidase family. CD73 is an ecto 5’Nucleotidase expressed by most cell types. CD73 hydrolyzes extracellular nucleotides into membrane permeable nucleosides. CD73 is one of several enzymes responsible for the production of extracellular adenosine, a signaling molecule that is involved in responses to inflammation and tissue injury. CD73 is a lymphocyte maturation marker that has functions independent of its catalytic activity. CD73 is also a regulator of leukocyte extravasation, a function that requires its 5’Nucleotidase activity.CD73 has also been reported to regulate expression of pro-inflammatory molecules in mouse endothelium.

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