Name: Human UBE2D4 Recombinant Protein (GST Tag)
Synonyms: Ubiquitin-Conjugating Enzyme E2 D4;HBUCE1;Ubiquitin Carrier Protein D4;Ubiquitin-Protein Ligase D4;UBE2D4;UBCH5D
Expression host: E.coli
Sequence: Met 1-Met 147
Accesstion: Q9Y2X8
Species: Human
Mol_Mass: 43.5 kDa
AP_Mol_Mass: 40 kDa
Tag: N-GST
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5.
Reconstitution: Not Applicable
Background: Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational protein modification; protein K6-linked ubiquitination; protein K11-linked ubiquitination; protein K27-linked ubiquitination; protein K29-linked ubiquitination; protein K48-linked ubiquitination; and protein K63-linked ubiquitination. UBE2D4 regulate of protein metabolic process. UBE2D4 accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro; UBE2D4 able to promote polyubiquitination using all 7 ubiquitin Lys residues; but may prefer ‘Lys-11’ and ‘Lys-48’-linked poly-ubiquitination.
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