Name: Human PKLR Recombinant Protein (His Tag)

Synonyms: Pyruvate Kinase Isozymes R/L;Pyruvate Kinase 1;R-Type/L-Type Pyruvate Kinase;Red Cell/Liver Pyruvate Kinase;PKLR;PK1;PKL

Expression host: HEK293 Cells

Sequence: Met 1-Ser574

Accesstion: P30613

Species: Human

Mol_Mass: 62.9 kDa

AP_Mol_Mass: 58 kDa

Tag: C-His

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin:

Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 5% Trehalose, 5% Mannitol, 0.02% Tween 80, 50% Glycerol, 1mM EDTA, 1mM DTT, pH8.0.

Reconstitution: Not Applicable

Background: Pyruvate Kinase Isozymes R/L (PKLR) belongs to the pyruvate kinase family, There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. L type is major isozyme in the liver; R is found in red cells; M1 is the main form in muscle, heart and brain; M2 is found in early fetal tissues. PKLR exists as a homotetramer and catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in PKLR are also the cause of pyruvate kinase deficiency of red cells, which is a frequent cause of hereditary non-spherocytic hemolytic anemia.

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