Name: Human PCSK9 Recombinant Protein (His Tag/HA/AVI)
Synonyms: Proprotein Convertase Subtilisin/Kexin Type 9;Neural Apoptosis-Regulated Convertase 1;NARC-1;Proprotein Convertase 9;PC9;Subtilisin/Kexin-Like Protease PC9;PCSK9;NARC1
Expression host: HEK293 Cells
Sequence: Gln31-Gln692(Val474Ile,Gly670Glu)
Accesstion: Q8NBP7
Species: Human
Mol_Mass: 14&62 kDa
AP_Mol_Mass: 18&58-70&90-150 kDa
Tag: C-His-HA-Avi
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4.
Reconstitution: Not Applicable
Background: Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER ; the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2); and play a role in the neural development.
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