Name: Human AMIGO2 Recombinant Protein (His Tag)

Synonyms: Amphoterin-Induced Protein 2;AMIGO-2;Alivin-1;Differentially Expressed in Gastric Adenocarcinomas;DEGA;ALI1

Expression host: HEK293 Cells

Sequence: Gly40-His393

Accesstion: Q86SJ2

Species: Human

Mol_Mass: 41.3 kDa

AP_Mol_Mass: 58-85 kDa

Tag: C-His

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin:

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Amphoterin-Induced Protein 2 (AMIGO2) is a single-pass type I membrane protein which belongs to the AMIGO family of immunoglobulin superfamily. Mature AMIGO2 contains an Ig-like C2-type (immunoglobulin-like) domain; 6 LRR (leucine-rich) repeats; a LRRCT domain; as well as a LRRNT domain. AMIGO2 is mainly expressed in in breast; ovary; cervix; and uterus; although lower in lung; colon; and rectum. AMIGO2 required for depolarization-dependent survival of cultured cerebellar granule neurons. AMIGO2 may mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. AMIGO2 may contribute to signal transduction through its intracellular domain; and may be required for tumorigenesis of a subset of gastric adenocarcinomas.

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