Name: Human MGMT Recombinant Protein (His Tag)

Synonyms: Methylated-DNA–protein-cysteine methyltransferase;6-O-methylguanine-DNAmethyltransferase;O-6-methylguanine-DNA-alkyltransferase;MGMT

Expression host: E.coli

Sequence: Met 1-Asn207

Accesstion: P16455

Species: Human

Mol_Mass: 23.8 kDa

AP_Mol_Mass: 25 kDa

Tag: N-His

Purity: > 90 % as determined by reducing SDS-PAGE.


Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl,1mM DTT,1mM EDTA,500mM NaCl,0.1%Trition X-100,pH 8.0.

Reconstitution: Not Applicable

Background: MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-methyl-L-cysteine.

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