Name: Human MAN1B1 Recombinant Protein (His Tag)

Synonyms: Endoplasmic Reticulum Mannosyl-Oligosaccharide 1;2-Alpha-Mannosidase;ER Alpha-1;2-Mannosidase;ER Mannosidase 1;ERMan1;Man9GlcNAc2-Specific-Processing Alpha-Mannosidase;Mannosidase Alpha Class 1B Member 1;MAN1B1

Expression host: HEK293 Cells

Sequence: Asp106-Ala699

Accesstion: Q9UKM7

Species: Human

Mol_Mass: 68.7 kDa

AP_Mol_Mass: 58-80 kDa

Tag: C-His

Purity: > 95 % as determined by reducing SDS-PAGE.


Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl,10mM reduced Glutathione,pH 8.0.

Reconstitution: Not Applicable

Background: Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.

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