Name: Human AKR1C4 Recombinant Protein (His Tag)

Synonyms: Aldo-Keto Reductase Family 1 Member C4;3-Alpha-HSD1;3-Alpha-Hydroxysteroid Dehydrogenase Type I;Chlordecone Reductase;CDR;Dihydrodiol Dehydrogenase 4;DD-4;DD4;HAKRA;AKR1C4;CHDR

Expression host: E.coli

Sequence: Met 1-Tyr323

Accesstion: P17516

Species: Human

Mol_Mass: 39.3 kDa

AP_Mol_Mass: 35-40 kDa

Tag: N-His

Purity: > 90 % as determined by reducing SDS-PAGE.


Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.

Reconstitution: Not Applicable

Background: Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-α-Androstan-3-α,17-β-diol (3-α-diol). In addition, AKR1C4 also has some 20-α-Hydroxysteroid Dehydrogenase activity.

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