Name: Human IMP1/IMPA1 Recombinant Protein (His Tag)
Synonyms: Inositol Monophosphatase 1;IMP 1;IMPase 1;Inositol-1(or 4)-Monophosphatase 1;Lithium-Sensitive Myo-Inositol Monophosphatase A1;IMPA1;IMPA
Expression host: E.coli
Sequence: Met 1-Asp277
Accesstion: P29218
Species: Human
Mol_Mass: 32.3 kDa
AP_Mol_Mass: 30 kDa
Tag: N-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.25.
Reconstitution: Not Applicable
Background: Inositol Monophosphatase 1 (IMPA1) belongs to the inositol monophosphatase family. IMPA1 is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, IMPA1 can use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. IMPA1 has been implicated as the pharmacological target for lithium action in brain. IMPA1 shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. In addition, IMPA1 plays a improtant role in intracellular signal transduction.
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