Name: Human GITR/TNFRSF18 Recombinant Protein (mFc Tag)

Synonyms: Tumor necrosis factor receptor superfamily member 18;TNFRSF18;Glucocorticoid-induced TNFR-related protein;CD357;TNFRSF18;AITR;GITR

Expression host: HEK293 Cells

Sequence: Gln26-Glu161(Thr45Ala)

Accesstion: Q9Y5U5

Species: Human

Mol_Mass: 41.1 kDa

AP_Mol_Mass: 40-55 kDa

Tag: C-mFc

Purity: > 90 % as determined by reducing SDS-PAGE.


Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Tumor necrosis factor receptor superfamily member 18(GITR) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1; TRAF2; and TRAF3; but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

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