enes at this time have been associated using the pathogen manipulation of your host, as the use of sugars like fructose and amino acids are important resources to get a prosperous colonization, as described in P. infestans (Botero et al., 2018). This also indicates that the interaction involving S. betaceum and P. betacei is compatible, as the induction of expression of these genes correlates with a additional susceptible interaction (Duan et al., 2020). With the functional category for secondary metabolite production, at 24 hpi there was an overall enrichment, in specific of biosynthesis of terpenoid, phenylpropanoid, and lignin, frequently active defense pathways against biotic and abiotic tension (Paolinelli-Alfonso et al., 2016). The synthesis of a secondary wall containing lignin assists within the reinforcement in the wall and hinders the entry of your pathogen (Miedes et al., 2014). Likewise, the p38 MAPK list activation of terpenoid and phenylpropanoid produces phytoalexins, which present antimicrobial properties and accumulate in dying cells (Bell et al., 1986). Nonetheless, the expression of phytoalexins in early infection is related to an incompatible interaction (host resistance) (Bell et al., 1986). At 72 hpi, we observed a clear response of the plant expression to the pathogen switch: genes related to intracellular signaling and HR are activated. Noteworthy, ERF, putative late blight protein R1-A10 and R1B23, and senescence-specific cysteine protease SAG12 had been expressed, suggesting an induced leaf senescence, triggered by the pathogen to finish the infection cycleFrontiers in Plant Science | frontiersin.orgOctober 2021 | Volume 12 | ArticleBautista et al.Solanum betaceum Response P. betacei(Noh and Amasino, 1999). As infection approached 96 hpi, genes connected to these terms continue their induction with addition to senescence associated terms and jasmonic acid mGluR2 Formulation metabolic approach. The jasmonate and ethylene signal pathways are normally associated with the response to necrotrophic pathogens (Sun, 2017).AUTHOR CONTRIBUTIONSSR, AB, and NG-P planned and designed the research. NG-P, DBa, and MCB performed the experiments. DBa, DBo, JD, AB, and SR analyzed the data. DBa, JD, MC, and SR wrote the manuscript. All authors contributed for the report and approved the submitted version.CONCLUSIONIn conclusion, we obtained the initial time-series transcriptome of S. betaceum with a complete expression profile across infection triggered by P. betacei. From these data, we observed a close interaction in between the host transcriptional response and also the hemibiotrophic infection tactic from the pathogen, exhibiting a dynamic defense-related gene response all through the course of infection. We observed unique upregulated genes, related to susceptibility and resistance, that elucidate the continuous response in this compatible interaction: in the recognition of the pathogen as well as the activation of defense related pathways towards the final stages of infection together with the expression of genes related with cell death. We hypothesized the nature of this interaction as ETS, using a reprogramming of the host transcription caused by the pathogen for crucial resources to help in its colonization. Further analysis with resistant cultivars might be helpful to know the molecular mechanisms underlying resistance in tree tomato.FUNDINGThis operate was supported by the Department of Biological Sciences at Universidad de los Andes as well as the Study Fund on the School of Sciences plus the Workplace of th